GNG4 (E5O7M) Rabbit mAb #74558
- WB
Supporting Data
| REACTIVITY | H M |
| SENSITIVITY | Endogenous |
| MW (kDa) | 9 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
G protein subunit gamma 4 (GNG4) is a member of the G protein γ family and plays a role in transducing signals from GPCRs (3,4). In humans and mice, 14 γ G protein subunits have been identified (5). GNG4 plays critical roles in guanosine GDP synthesis, guanosine triphosphatase (GTPase) activity, and the regulation of G protein-effector interactions (6,7). GNG4 has been reported to act as a tumor suppressor gene in glioblastoma (8). Expression of GNG4 has been identified as an immunotherapy marker associated with colon cancer prognosis, and is associated with multiple malignant phenotypes of lung adenocarcinoma (9,10).
- Lin, Y.L. et al. (2020) J Cancer Res Clin Oncol 146, 2179-2188.
- Chaudhary, P.K. and Kim, S. (2021) Cells 10, 3288. doi: 10.3390/cells10123288.
- Crespo, P. et al. (1994) Nature 369, 418-20.
- Khan, S.M. et al. (2013) Pharmacol Rev 65, 545-77.
- Smrcka, A.V. (2008) Cell Mol Life Sci 65, 2191-214.
- Wang, J. et al. (2023) J Cell Mol Med 27, 2517-2532.
- Smrcka, A.V. and Fisher, I. (2019) Cell Mol Life Sci 76, 4447-4459.
- Pal, J. et al. (2016) Genes Cancer 7, 136-47.
- Liang, L. et al. (2021) J Oncol 2021, 9931984.
- Zhou, B. et al. (2022) Thorac Cancer 13, 369-379.
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