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KCNE1 Antibody #3486

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Inquiry Info. # 3486

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    Product Specifications

    REACTIVITY H M R Mk
    SENSITIVITY Endogenous
    MW (kDa) 15
    SOURCE Rabbit
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 
    • Mk-Monkey 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:100

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    KCNE1 Antibody detects endogenous levels of total KCNE1 protein.

    Species Reactivity:

    Human, Mouse, Rat, Monkey

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asp76 of human KCNE1 protein. Antibodies are purified by protein A and peptide affinity chromatography.

    Background

    Voltage-gated potassium channels play a variety of important roles in human health and disease (1,2). KCNE1, also known as MinK, belongs to a family of small transmembrane proteins (KCNE1, 2, 3, 4, and KCNE1L) that modulate the activity of several voltage-gated K+ channels (3-5). KCNE1 functions as the modulatory β-subunit of the pore-forming α-subunit KCNQ1, and alters several biophysical properties of KCNQ1 channels (6,7). Research studies have shown that several inherited mutations in KCNE1 result in long QT syndrome (8-10) and deafness (11).

    Alternate Names

    cardiac delayed rectifier potassium channel protein; Delayed rectifier potassium channel subunit IsK; FLJ18426; FLJ38123; FLJ94103; IKs producing slow voltage-gated potassium channel subunit beta Mink; ISK; JLNS; JLNS2; KCNE1; Long QT syndrome 5; LQT2/5; LQT5; MGC33114; Minimal potassium channel; MinK; potassium channel, voltage gated subfamily E regulatory beta subunit 1; Potassium voltage-gated channel subfamily E member 1; potassium voltage-gated channel subfamily E regulatory subunit 1; potassium voltage-gated channel, Isk-related family, member 1; potassium voltage-gated channel, Isk-related subfamily, member 1; voltage gated potassiun channel accessory subunit

    For Research Use Only. Not for Use in Diagnostic Procedures.
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