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  3. Histone Deacetylase 6 (HDAC6) Antibody

Histone Deacetylase 6 (HDAC6) Antibody #2162

Inquiry Info. # 2162

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    Product Specifications

    REACTIVITY
    SENSITIVITY
    MW (kDa) 134
    SOURCE Rabbit

    Product Information

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

    Specificity / Sensitivity

    Histone Deacetylase 6 (HDAC6) Antibody detects endogenous levels of total HDAC6 protein. This antibody does not cross-react with other HDACs.

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding amino acid 1200 of human HDAC6. Antibodies are purified by protein A and peptide affinity chromatography.

    Background

    Acetylation of the histone tail causes chromatin to adopt an "open" conformation, allowing increased accessibility of transcription factors to DNA. The identification of histone acetyltransferases (HATs) and their large multiprotein complexes has yielded important insights into how these enzymes regulate transcription (1,2). HAT complexes interact with sequence-specific activator proteins to target specific genes. In addition to histones, HATs can acetylate nonhistone proteins, suggesting multiple roles for these enzymes (3). In contrast, histone deacetylation promotes a "closed" chromatin conformation and typically leads to repression of gene activity (4). Mammalian histone deacetylases can be divided into three classes on the basis of their similarity to various yeast deacetylases (5). Class I proteins (HDACs 1, 2, 3, and 8) are related to the yeast Rpd3-like proteins, those in class II (HDACs 4, 5, 6, 7, 9, and 10) are related to yeast Hda1-like proteins, and class III proteins are related to the yeast protein Sir2. Inhibitors of HDAC activity are now being explored as potential therapeutic cancer agents (6,7).

    Alternate Names

    CPBHM; FLJ16239; HD6; HDAC6; Histone deacetylase 6; JM21; KIAA0901; PPP1R90; protein phosphatase 1, regulatory subunit 90; Tubulin-lysine deacetylase HDAC6

    Database Links

    UniProt ID: Q9UBN7


    Entrez-Gene Id: 10013


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    For Research Use Only. Not for Use in Diagnostic Procedures.
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