Render Target: STATIC
Render Timestamp: 2024-12-06T11:15:41.674Z
Commit: 224419269841c11382c4555dbee545259bf6c379
XML generation date: 2024-09-30 01:54:58.891
Product last modified at: 2024-11-02T14:30:07.834Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

HMOX2/HO-2 (D9J9U) Rabbit mAb #32790

Filter:
  • WB

    Supporting Data

    REACTIVITY H M R Hm Mk
    SENSITIVITY Endogenous
    MW (kDa) 36
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 
    • Hm-Hamster 
    • Mk-Monkey 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    HMOX2/HO-2 (D9J9U) Rabbit mAb recognizes endogenous levels of total HMOX2/HO-2 protein.

    Species Reactivity:

    Human, Mouse, Rat, Hamster, Monkey

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala131 of human HMOX2/HO-2 protein.

    Background

    Heme oxygenases (HMOX or HO) catalyze the rate-limiting step of the oxidative degradation of heme into iron, carbon monoxide, and biliverdin (1). Biliverdin is then converted to bilirubin (2). Heme is a strong pro-oxidant whereas bilirubin is a strong antioxidant (2). Research studies suggest disregulation of heme oxygenases may contribute to oxidative stress-related diseases (2). There are three isozymes of heme oxygenases: HMOX1/HO-1, HMOX2/HO-2, and HMOX3/HO-3 (1,2). HMOX1/HO-1 is inducible by heme and other stress stimuli (1,3). HMOX2/HO-2 and HMOX3/HO-3 are constitutively expressed (1,3).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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