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Primary Antibodies /
HNF4α (E410) Antibody

HNF4α (E410) Antibody #3105

Inquiry Info. # 3105

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Product Specifications

REACTIVITY
SENSITIVITY	Endogenous
MW (kDa)	52
SOURCE	Rabbit

Product Information

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

HNF4α (E410) Antibody detects endogenous levels of total HNF4α protein.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the sequence around E410 of human HNF4α. Antibodies are purified by protein A and peptide affinity chromatography.

Background

Hepatocyte nuclear factor 4α (HNF4α) is a transcription factor that belongs to the steroid hormone receptor superfamily and is enriched in liver (1). HNF4α, in association with PGC-1α, activates gluconeogenic genes such as phosphoenolpyruvate carboxykinase and glucose-6-phosphatase genes in fasted livers (2,3). Conditional knockout of the HNF4α gene in the mouse liver destroys lipid homeostasis and leads to lipid accumulation in the liver and a reduction of serum cholesterol and triglyceride levels (4). Mutations in HNF4α have been linked to maturity-onset diabetes of the young (MODY) (5).

Alternate Names

FLJ39654; FRTS4; hepatic nuclear factor 4 alpha; hepatocyte nuclear factor 4 alpha; Hepatocyte nuclear factor 4-alpha; hepatocyte nuclear factor 4, alpha; HNF-4-alpha; HNF4; HNF4 alpha; HNF4A; HNF4a7; HNF4a8; HNF4a9; HNF4alpha; HNF4alpha10/11/12; MODY; MODY1; NR2A1; NR2A21; Nuclear receptor subfamily 2 group A member 1; TCF; TCF-14; TCF14; Transcription factor 14; Transcription factor HNF-4; transcription factor-14

Database Links

UniProt ID: P41235

Entrez-Gene Id: 3172

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For Research Use Only. Not for Use in Diagnostic Procedures.

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