Render Target: STATIC
Render Timestamp: 2024-12-02T11:02:13.663Z
Commit: cd2fae6ca3f811b1ddb1df24ac291ed56d5d501b
XML generation date: 2024-09-30 01:57:55.497
Product last modified at: 2024-11-26T19:15:08.664Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

HoxA10 (E5X4L) Rabbit mAb #58891

Filter:
  • WB
  • IP

    Supporting Data

    REACTIVITY H M R Mk
    SENSITIVITY Endogenous
    MW (kDa) 52
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 
    • Mk-Monkey 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:50

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    HoxA10 (E5X4L) Rabbit mAb recognizes endogenous levels of total HoxA10 protein. This antibody detects a band of unknown origin around 32 kDa.

    Species Reactivity:

    Human, Mouse, Rat, Monkey

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu188 of human HoxA10 protein.

    Background

    HOXA10 is a member of the HOXA cluster which, along with the HOXB, HOXC, and HOXD clusters, governs embryonic patterning along the cranio-caudal axis (1,2). HOXA10 was originally identified in hematopoietic cells, where it is alternatively spliced into two isoforms, the larger being expressed in early stages of myeloid differentiation (2,3). Expression of HOXA10 can be regulated by estrogen and progesterone and is important for uterine implantation (4-6). HOXA10 is a transcription factor that partners with Pbx proteins to bind DNA, and this process can be affected by tyrosine phosphorylation (7,8). Overexpression of HOXA10 has been shown to contribute to acute myeloid leukemia and is associated with poor prognosis (9,10).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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