| Cat. # | Size | Qty. | Price |
|---|---|---|---|
| 47289SF | 100 µg |
|
| REACTIVITY | H Mk |
| SENSITIVITY | Endogenous |
| MW (kDa) | 27 |
| Source/Isotype | Mouse IgG1 |
Product Information
Human, Monkey
Monoclonal antibody is produced by immunizing animals with full length HSP27 protein.
Heat shock protein (HSP) 27 is one of the small HSPs that are constitutively expressed at different levels in various cell types and tissues. Like other small HSPs, HSP27 is regulated at both the transcriptional and posttranslational levels (1). In response to stress, the HSP27 expression increases several-fold to confer cellular resistance to the adverse environmental change. HSP27 is phosphorylated at Ser15, Ser78, and Ser82 by MAPKAPK-2 as a result of the activation of the p38 MAP kinase pathway (2,3). Phosphorylation of HSP27 causes a change in its tertiary structure, which shifts from large homotypic multimers to dimers and monomers (4). It has been shown that phosphorylation and increased concentration of HSP27 modulates actin polymerization and reorganization (5,6).
Explore pathways related to this product.
STRING - Known and Predicted Protein-Protein Interactions.
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