Render Target: STATIC
Render Timestamp: 2025-03-20T11:13:39.366Z
Commit: 779953b12a5930618aae6aca7c87fb286faeb1d7
XML generation date: 2025-03-07 13:19:27.628
Product last modified at: 2025-01-01T09:04:14.110Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

ICA1L (F6I4E) Rabbit mAb #53771

Filter:
  • WB

    Supporting Data

    REACTIVITY M R
    SENSITIVITY Endogenous
    MW (kDa) 55
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • M-Mouse 
    • R-Rat 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    ICA1L (F6I4E) Rabbit mAb recognizes endogenous levels of total ICA1L protein. A band of unknown origin at 21 kDa is detected by western blot.

    Species Reactivity:

    Mouse, Rat

    The antigen sequence used to produce this antibody shares 100% sequence homology with the species listed here, but reactivity has not been tested or confirmed to work by CST. Use of this product with these species is not covered under our Product Performance Guarantee.

    Species predicted to react based on 100% sequence homology:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val134 of human ICA1L protein.

    Background

    Islet cell autoantigen 1-like protein (ICA1L) expression is enriched in glutamatergic excitatory neurons (1). ICA1L plays a crucial role in myelination, where it has recently been linked to multiple sclerosis (MS) pathogenesis (2,3). ICA1L is a newly discovered risk gene for MS but has previously been identified as a risk gene for cerebrovascular disease by several genome-wide association studies (GWAS). Recent proteome-wide association studies (PWAS) found that diseases associated with ICA1L also include cerebrovascular disease (4-7).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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