Render Target: STATIC
Render Timestamp: 2025-02-11T11:04:18.947Z
Commit: 7500bcdc731e9059bbdfbdbe9e72caa896e426e8
XML generation date: 2024-09-30 01:59:05.737
Product last modified at: 2025-01-07T15:30:08.548Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

IFI35 (E3A8S) Rabbit mAb #35909

Filter:
  • WB

    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 32
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    IFI35 (E3A8S) Rabbit mAb recognizes endogenous levels of total IFI35 protein.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val250 of human IFI35 protein.

    Background

    Interferon-induced 35 kDa protein (IFI35) is a leucine zipper-containing protein that is upregulated in response to type I and type II interferons (1,2). Research studies have demonstrated that intracellular pools of IFI35, in complex with NMI, negatively regulate innate immune antiviral signaling by blunting type I interferon production (3,4). Extracellularly, IFI35 has been shown to modulate the innate immune response by functioning as a proinflammatory damage-associated molecular pattern (DAMP) upon release by activated macrophages (5,6).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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