Render Target: STATIC
Render Timestamp: 2024-10-09T09:45:16.506Z
Commit: f04ddd7fea9fb3592f59f61482fcb94610d25cbe
1% for the planet logo
PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

IL-2Rγ (E2Z5W) Rabbit mAb #18526

Filter:
  • WB
  • IP
  • F

    Supporting Data

    REACTIVITY M
    SENSITIVITY Endogenous
    MW (kDa) 60-80
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    • F-Flow Cytometry 
    Species Cross-Reactivity Key:
    • M-Mouse 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:200
    Flow Cytometry (Live) 1:50

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    IL-2Rγ (E2Z5W) Rabbit mAb recognizes endogenous levels of total IL-2Rγ protein.

    Species Reactivity:

    Mouse

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with mouse IL-2Rγ recombinant protein.

    Background

    IL-2Rγ (Cytokine receptor common subunit gamma, γc) is part of the interleukin-2 (IL-2) receptor, comprised of alpha, beta, and gamma chains (1-6). The gamma chain is required for the formation of high- and intermediate-affinity receptors, which consist of alpha beta gamma heterotrimers and beta gamma heterodimers (1). IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21 all share the same common gamma chain, which was originally discovered as the gamma chain of the IL-2 receptor (3-6). The γ chain family of cytokines contribute to lymphocyte homeostasis by controlling aspects of lymphocyte development, growth, differentiation, and survival (5,6). In humans, a mutation in IL-2Rγ results in X-linked severe combined immunodeficiency (XSCID), which is a disease characterized by the absence of T and NK cells, with nonfunctional B cells (2).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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