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INSM1 (BLR272L) Rabbit mAb #72247

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  • IHC

    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa)
    Source/Isotype Rabbit IgG
    Application Key:
    • IHC-Immunohistochemistry 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Immunohistochemistry (Paraffin) 1:800 - 1:3200

    Storage

    Supplied in a PBS-based buffer with ~1% BSA and less than 0.1% sodium azide. Stable for 6 months when stored at 4°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    INSM1 (BLR272L) Rabbit mAb recognizes endogenous levels of INSM1 protein.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a peptide representing a region between residue 50 and 100 of human INSM1 protein.

    Background

    Insulinoma-associated protein 1 (INSM1), originally named IA-1, is a zinc-finger protein cloned from an insulinoma and glucagonoma subtraction library (1). It is a transcriptional repressor expressed in the developing pancreas and nervous system and targets genes such as NeuroD/β2 and insulin, critical regulators of neuroendocrine differentiation during development (2-5). Most importantly, INSM1 has emerged as a key marker in neuroendocrine tumor types, including small cell lung cancer (SCLC), medullary thyroid carcinoma, pheochromocytoma Merkel cell carcinoma, neuroblastoma, and neuroendocrine tumors of the pancreas, breast, colon, bladder, and prostate (6-9). Some studies have also shown that the level of INSM1 expression may have prognostic value (10,11).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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