Integrin β5 (D24A5) Rabbit mAb #3629
- WB
- IP
- IF
Supporting Data
| REACTIVITY | H M R Mk |
| SENSITIVITY | Endogenous |
| MW (kDa) | 90 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
- IF-Immunofluorescence
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
- Mk-Monkey
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:50 |
| Immunofluorescence (Immunocytochemistry) | 1:1600 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
The αVβ5 integrin is expressed in various tissues and cell types, including endothelia, epithelia and fibroblasts (4). It plays a role in matrix adhesion to VN, FN, SPARC and bone sialoprotein (5) and functions in the invasion of gliomas and metastatic carcinoma cells (6,7). αVβ5 integrin plays a major role in growth-factor-induced tumor angiogenesis, where cooperative signaling by the αVβ5 integrin and growth factors regulates endothelial cell proliferation and survival (8).
- Hood, J.D. and Cheresh, D.A. (2002) Nat. Rev. Cancer 2, 91-100.
- Liu, S. et al. (2000) J. Cell Sci. 113, 3563-3571.
- van der Flier, A. and Sonnenberg, A. (2001) Cell Tissue Res. 305, 285-298.
- Pasqualini, R. et al. (1993) J. Cell Sci. 105, 101-111.
- Plow, E.F. et al. (2000) J. Biol. Chem. 275, 21785-21788.
- Sun, L.C. et al. (2007) Cancer Lett. 246, 157-166.
- Enns, A. et al. (2005) Eur. J. Cancer 41, 1065-1072.
- Alghisi, G.C. and Rüegg, C. (2006) Endothelium 13, 113-135.
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