Render Target: STATIC
Render Timestamp: 2024-12-09T10:54:00.823Z
Commit: 224419269841c11382c4555dbee545259bf6c379
XML generation date: 2024-09-30 01:58:14.187
Product last modified at: 2024-09-30T08:00:39.359Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

ITM2A (E7G8A) Rabbit mAb #73561

Filter:
  • WB
  • IF

    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 12, 39
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IF-Immunofluorescence 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunofluorescence (Immunocytochemistry) 1:6400 - 1:25600

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    ITM2A (E7G8A) Rabbit mAb recognizes endogenous levels of total ITM2A protein.

    Species Reactivity:

    Human

    The antigen sequence used to produce this antibody shares 100% sequence homology with the species listed here, but reactivity has not been tested or confirmed to work by CST. Use of this product with these species is not covered under our Product Performance Guarantee.

    Species predicted to react based on 100% sequence homology:

    Mouse, Rat

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro9 of human ITM2A protein.

    Background

    Integral membrane protein 2A (ITM2A) is a type II membrane protein. ITM2A belongs to a family of membrane proteins defined by a conserved BRICHOS domain, a stretch of approximately 100 amino acids that may function as chaperone proteins (1). ITM2A, like other BRICHOS domain-containing proteins, may undergo proteolytic cleavage as it matures (2,3). BRICHOS domain-containing proteins exhibit anti-amyloidogenic activity, suggesting that these proteins may modulate formation of amyloid fibrils and oligomers (4). Aberrant amyloid formation is associated with amyloid diseases like Alzheimer’s disease. The specific function of ITM2A is unclear but it may play a redundant role in the development and function of T cells (5).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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