Fresh savings just popped up! 25% off 3 or more products. | Start Saving >>
LRF/Pokemon Antibody

LRF/Pokemon Antibody #13097

This product is discontinued

We recommend the following alternatives

  • WB
  • IHC
  • IF
  • F
H M R Mk

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

LRF/Pokemon Antibody recognizes endogenous levels of total LRF (Pokemon) protein.

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro241 of human LRF (pokemon) protein. Antibodies are purified by protein A and peptide affinity chromatography.

Zinc finger and BTB domain-containing protein 7A (LRF, Pokemon, FBI1) is a transcriptional repressor encoded by the ZBTB7A gene that belongs to the POK (POZ and Kruppel)/ZBTB (zinc finger and BTB) family (1). LRF is broadly expressed with elevated expression in a variety of cancers relative to normal tissues, including non-small cell lung cancer, breast cancer, ovarian cancer, prostate cancer, and hepatocellular carcinoma (1-8). Research studies suggest that LRF acts as an oncogene through various mechanisms including repression of the tumor suppressors ARF and Rb, and repression of the cell cycle arrest factor p21Cip1 (9-11). The LRF transcription factor plays key roles during several stages of hematopoiesis including promoting lymphoid progenitor cells to commit to B cell differentiation by repressing T cell-promoting Notch signals, and promoting cell survival during terminal erythroid differentiation through suppression of the proapoptotic factor Bim (12,13).

  1. Lee, S.U. and Maeda, T. (2012) Immunol Rev 247, 107-19.
  2. Apostolopoulou, K. et al. (2007) J Pathol 213, 294-302.
  3. Zhao, Z.H. et al. (2008) Lung Cancer 62, 113-9.
  4. Qu, H. et al. (2010) Cancer Invest 28, 672-8.
  5. Aggarwal, A. et al. (2010) Exp Mol Pathol 89, 140-8.
  6. Jiang, L. et al. (2010) Mol Cancer 9, 318.
  7. Aggarwal, H. et al. (2011) Exp Mol Pathol 90, 226-30.
  8. Fang, F. et al. (2012) Cancer 118, 134-46.
  9. Maeda, T. et al. (2005) Nature 433, 278-85.
  10. Jeon, B.N. et al. (2008) J Biol Chem 283, 33199-210.
  11. Choi, W.I. et al. (2009) J Biol Chem 284, 12633-44.
  12. Maeda, T. et al. (2007) Science 316, 860-6.
  13. Maeda, T. et al. (2009) Dev Cell 17, 527-40.
Entrez-Gene Id
Swiss-Prot Acc.
For Research Use Only. Not For Use In Diagnostic Procedures.

Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
SignalSilence is a registered trademark of Cell Signaling Technology, Inc.
Tween is a registered trademark of ICI Americas, Inc.

Upstream / Downstream


Explore pathways related to this product.