Render Target: STATIC
Render Timestamp: 2024-12-02T11:15:21.964Z
Commit: cd2fae6ca3f811b1ddb1df24ac291ed56d5d501b
XML generation date: 2024-11-18 16:03:12.255
Product last modified at: 2024-11-19T09:00:16.489Z
1% for the planet logo
PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

MAD2L2 (F9H9U) Rabbit mAb #98423

Filter:
  • WB
  • IP

    Supporting Data

    REACTIVITY H M R
    SENSITIVITY Endogenous
    MW (kDa) 24
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:100

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    MAD2L2 (F9H9U) Rabbit mAb recognizes endogenous levels of total MAD2L2 protein.

    Species Reactivity:

    Human, Mouse, Rat

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val203 of human MAD2L2 protein.

    Background

    Mitotic arrest deficient 2 like 2 (MAD2L2), also known as REV7, is a Mad family mitotic spindle assembly checkpoint protein that regulates progression into anaphase of mitosis (1), and functions in translesion DNA synthesis and DNA double-strand break (DSB) repair (2). MAD2L2 expression is high in human cancer, and expression levels are correlated with prognosis. MAD2L2 expression may predict the effectiveness of chemotherapy and PARP inhibitors, and MAD2L2 inhibitors may enhance the effects of these treatments (3).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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