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MAGI3-Akt3 Fusion Protein (D4D3P) Rabbit mAb #48086
This product is discontinued
Gallery: MAGI3-Akt3 Fusion Protein (D4D3P) Rabbit mAb #48086
MAGI3-Akt3 Fusion Protein (D4D3P) Rabbit mAb recognizes transfected MAGI3-Akt3 fusion protein.
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding the fusion site of MAGI3-Akt3 fusion protein.
MAGI3-Akt3 fusion was first detected in triple-negative breast cancer tissues in a sequence analysis research study (1). Rearrangement occurs between the genes MAGI3 (membrane-associated guanylate kinase, WW and PDZ domain containing 3) on chromosome 1p and Akt3 on chromosome 1q, leading to a translocation from intron 9 in MAGI3 to intron1 of Akt3. This rearrangement yields an in-frame fusion gene that translates into a MAGI3-Akt3 fusion protein. Overexpression studies show that MAGI3-Akt3 fusion protein leads to the constitutive activation of Akt kinase (1). Further research studies demonstrate that this fusion is not a recurrent event in triple-negative breast cancer (2,3).
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