| Cat. # | Size | Qty. | Price |
|---|---|---|---|
| 9926T | 1 Kit (3 x 20 microliters) |
|
$ 303 |
| Product Includes | Quantity | Applications | Reactivity | MW(kDa) | Isotype |
|---|---|---|---|---|---|
| p44/42 MAPK (Erk1/2) (137F5) Rabbit mAb 4695 | 20 µl |
|
H M R Hm Mk Mi Dm Z B Dg Pg Ce | 42, 44 | Rabbit IgG |
| SAPK/JNK Antibody 9252 | 20 µl |
|
H M R Hm Mk Z B Sc | 46, 54 | Rabbit |
| p38 MAPK (D13E1) XP® Rabbit mAb 8690 | 20 µl |
|
H M R Hm Mk B Pg | 40 | Rabbit IgG |
| Anti-rabbit IgG, HRP-linked Antibody 7074 | 100 µl |
|
Rab | Goat |
Product Information
p44/42 MAP Kinase (137F5) Rabbit mAb is produced by immunizing animals with a synthetic peptide corresponding to residues near the C-terminus of rat p44 MAP kinase. p38 MAPK (D13E1) XP® Rabbit mAb is produced by immunizing animals with a synthetic peptide corresponding to the carboxy terminus of human p38 protein. SAPK/JNK Antibody is produced by immunizing animals with a recombinant human JNK2 fusion protein. Polyclonal antibodies are purified by protein A and peptide affinity chromatography.
p44/42 MAPK (Erk1/2), SAPK/JNK, and p38 MAPK function in protein kinase cascades that play a critical role in the regulation of cell growth, differentiation, and control of cellular responses to cytokines and stress. p44/42 MAPK is activated by growth and neurotrophic factors. Activation occurs through phosphorylation of threonine and tyrosine residues (Thr202 and Tyr204 in human Erk1) at the sequence T*EY* by a single upstream MAP kinase kinase (MEK). SAPK/JNK and p38 MAPK are activated by inflammatory cytokines and by a wide variety of cellular stresses. Activation of SAPK/JNK occurs via phosphorylation at Thr183 and Tyr185 by the dual specificity enzyme SEK/MKK4. Both MKK3 and SEK phosphorylate p38 MAPK on tyrosine and threonine at the sequence T*GY* to activate p38 MAP kinase (1-5).
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