MEF2C Antibody

Inquiry Info. # 9792

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Product Specifications

REACTIVITY
SENSITIVITY
MW (kDa)	48
SOURCE	Rabbit

Product Information

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

MEF2C Antibody detects endogenous levels of total MEF2C protein. This antibody does not cross-react with related family members.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ser419 of human MEF2C. Antibodies are purified by protein A and peptide affinity chromatography.

Background

MEF2C is a member of the MEF2 (myocyte enhancer factor 2) family of transcription factors. In mammals, there are four MEF2C-related genes (MEF2A, MEF2B, MEF2C and MEF2D) that encode proteins that exhibit significant amino acid sequence similarity within their DNA binding domains and, to a lesser extent, throughout the rest of the proteins (1). The MEF2 family members were originally described as muscle-specific DNA binding proteins that recognize MEF2 motifs found within the promoters of many muscle-specific genes (2,3). Recently, several groups have reported MEF2 binding activity and MEF2 proteins in a wide variety of cell types where these proteins appear to play an important role in growth factor- and stress-induced early gene responses (4-6).

Alternate Names

C5DELq14.3; DEL5q14.3; MADS box transcription enhancer factor 2, polypeptide C; MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C); MEF2C; myocyte enhancer factor 2C; Myocyte-specific enhancer factor 2C

Database Links

UniProt ID: Q06413

Entrez-Gene Id: 4208

Limited Uses

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For Research Use Only. Not for Use in Diagnostic Procedures.

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MEF2C Antibody #9792