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MEIS2 (F9I5S) Rabbit mAb #68488

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  • WB
  • IP

    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 65
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:50

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    MEIS2 (F9I5S) Rabbit mAb recognizes endogenous levels of total MEIS2 protein. This antibody does not cross-react with MEIS1 protein.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro414 of human MEIS2 protein.

    Background

    Hox, Pbx, and Meis are families of transcription factors that bind DNA via their homeodomains. Members from each family form heterodimers to give rise to complexes with unique DNA binding specificities. Homeodomain-containing proteins are frequently involved in normal developmental processes but can also be associated with tumorigenic states (1). MEIS proteins belong to the three amino acid loop extension (TALE) homeobox-containing transcription factor family. MEIS1 has been associated with leukemogenesis and neuroblastoma (2,3), while MEIS2 is known to play an important role in the transcriptional program that is induced in normal pancreatic development (4) and cardiogenesis (5).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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