Render Target: STATIC
Render Timestamp: 2024-09-17T10:01:57.183Z
Commit: 195d6e018d1f29a59e5c111fed767382e8d7f01b
1% for the planet logo
PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

Melanotransferrin (F3W8H) Rabbit mAb #20173

Filter:
  • WB
  • IP

    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 97
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:50

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    Melanotransferrin (F3W8H) Rabbit mAb recognizes endogenous levels of total melanotransferrin protein.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly668 of human melanotransferrin protein.

    Background

    Melanotransferrin, also known as MTF, MFI2, CD228, or p97, is a membrane-bound glycoprotein that is commonly associated with melanoma (1). Melanotransferrin shares structural similarity and iron-binding properties with the protein transferrin, although it does not appear to be involved with iron transport (2-4). Melanotransferrin is expressed at low levels in normal tissue but has elevated expression in melanoma (5,6). The exact biological function of melanotransferrin in melanoma is not yet fully understood, but it is believed to play a role in cell proliferation and invasion (7). Upregulation of melanotransferrin has also been observed in other forms of cancer, such as lung, colorectal, gastric, and oral squamous cell carcinoma (OSCC) (8-11).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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