Render Target: STATIC
Render Timestamp: 2024-10-11T10:41:59.829Z
Commit: 56767fe525c928647c8401233a175d0d607d385d
XML generation date: 2024-09-30 01:58:30.184
Product last modified at: 2024-09-30T08:01:11.292Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

MERS-CoV Membrane Protein (E2Z4Q) Rabbit mAb #56075

Filter:
  • WB

    Supporting Data

    REACTIVITY Vir
    SENSITIVITY Transfected Only
    MW (kDa) 20-30
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • Vir-Virus 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    MERS-CoV Membrane Protein (E2Z4Q) Rabbit mAb recognizes transfected levels of total MERS-CoV membrane protein. This antibody does not cross-react with membrane proteins from SARS coronaviruses (CoV-1, CoV-2).

    Species Reactivity:

    Virus

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gln184 of MERS-CoV membrane protein.

    Background

    Middle East Respiratory Syndrome (MERS) is a contagious viral respiratory infection, whose causative agent was identified as the MERS-related coronavirus (MERS-CoV) (1,2). MERS-CoV is a single-stranded mRNA betacoronavirus; similar to other infectious coronaviruses (e.g., SARS-CoV-2), the MERS-CoV genome encodes four key structural proteins (spike, envelope, membrane, and nucleocapsid) that make up the virion particle, in addition to at least 10 smaller open reading frames (ORFs) that encode the non-structural (accessory) proteins required for viral replication (3). The MERS membrane protein, like that of other betacoronaviruses, is an integral membrane protein and the most abundant of the structural proteins in a virus particle. Numerous studies have shown that the membrane protein of betacoronaviruses is more than just a structural protein; it plays multiple functional roles in orchestrating viral replication following host infection (4-7).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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