MKK3 Antibody

Inquiry Info. # 9232

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Product Specifications

REACTIVITY
SENSITIVITY	Endogenous
MW (kDa)	40
SOURCE	Rabbit

Product Information

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

MKK3 Antibody detects endogenous levels of total MKK3 protein. This antibody does not cross-react with MEK1, MEK2, MKK4 or MKK6.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the sequence of human MKK3. Antibodies are purified by protein A and peptide affinity chromatography.

Background

MKK3 and MKK6 are two closely related dual-specificity protein kinases that activate p38 MAP kinase (1-5). MKK3 and MKK6 both phosphorylate and activate p38 MAP kinase at its activation site, Thr-Gly-Tyr, but do not phosphorylate or activate Erk1/2 or SAPK/JNK. Phosphorylation of p38 MAP kinase dramatically stimulates its ability to phosphorylate protein substrates such as ATF-2 and Elk-1. MKK3 and MKK6 are both activated by different forms of cellular stress and inflammatory cytokines (4,5). Activation of MKK3 and MKK6 occurs through phosphorylation at Ser189 and Thr222 on MKK3 (2) and Ser207 and Thr211 on MKK6 (4,5).

Alternate Names

Dual specificity mitogen-activated protein kinase kinase 3; MAP kinase kinase 3; MAP2K3; MAPK/ERK kinase 3; MAPKK 3; MAPKK3; MEK 3; MEK3; mitogen-activated protein kinase kinase 3; MKK3; MP2K3; PRKMK3; SAPK kinase 2; SAPKK-2; SAPKK2; SKK2; Stress-activated protein kinase kinase 2

Database Links

UniProt ID: P46734

Entrez-Gene Id: 5606

Limited Uses

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For Research Use Only. Not for Use in Diagnostic Procedures.

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MKK3 Antibody #9232