MLLT1/ENL Antibody #12141
- WB
Inquiry Info. # 12141
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Product Specifications
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 80 |
| SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
MLL translocated to 1/eleven-nineteen-leukemia (MLLT1/ENL) is also found as part of the histone H3 Lys79 methyltransferase disruptor of telomeric silencing-like (Dot1L) complex that has been suggested to play a role in transcription elongation. This complex regulates the expression of genes, such as the Wnt-signaling pathway target genes that control cell proliferation and differentiation during development (12,13).
- Mohan, M. et al. (2010) Nat Rev Cancer 10, 721-8.
- Lin, C. et al. (2010) Mol Cell 37, 429-37.
- Drexler, H.G. et al. (2004) Leukemia 18, 227-32.
- Smith, E. et al. (2011) Genes Dev 25, 661-72.
- Shilatifard, A. et al. (1996) Science 271, 1873-6.
- Shilatifard, A. et al. (1997) Proc Natl Acad Sci U S A 94, 3639-43.
- Miller, T. et al. (2000) J Biol Chem 275, 32052-6.
- Lin, C. et al. (2011) Genes Dev 25, 1486-98.
- Yokoyama, A. et al. (2010) Cancer Cell 17, 198-212.
- Cho, S. et al. (2010) Cell Cycle 9, 1697-705.
- Shah, N. and Sukumar, S. (2010) Nat Rev Cancer 10, 361-71.
- Mohan, M. et al. (2010) Genes Dev 24, 574-89.
- Nguyen, A.T. and Zhang, Y. (2011) Genes Dev 25, 1345-58.
Alternate Names
CTC-503J8.6; ENL; ENL/MLL fusion; ENL/MLL fusion partner; LTG19; MLL/ENL fusion protein; MLLT1; MLLT1 super elongation complex subunit; MLLT1/MLL fusion; MLLT1/MLL fusion partner; myeloid/lymphoid or mixed-lineage leukemia; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog); Protein ENL; translocated to, 1; YEATS domain-containing protein 1; YEATS1
Limited Uses
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