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MMS19 (D5J8J) Rabbit mAb

MMS19 (D5J8J) Rabbit mAb #90637

This product is discontinued


Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

MMS19 (D5J8J) Rabbit mAb recognizes endogenous levels of total MMS19 protein.

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu892 of human MMS19 protein.

Iron-sulfur (Fe-S) clusters (ISC) are cofactors for many proteins that display a wide range of biological functions, such as DNA maintenance, transcription, translation, cellular metabolism, electron transport, and oxidative phosphorylation (1). While structurally simple, the synthesis and insertion of ISC into Fe-S proteins are complex processes that involve many different proteins. MMS19 (methyl-methanesulfonate sensitivity 19) is a key component of the cytosolic Fe-S protein assembly complex, acting as an adaptor for a subset of Fe-S proteins including XPD and FANCJ, therefore playing an important role in DNA repair and transcription (2-4). MMS19 may also function as a coactivator for the estrogen receptor (5). In addition it has been reported that MMS19 is in a complex that is localized to the mitotic spindle and is required for proper chromosome segregation during mitosis (6).

  1. Wang, J. and Pantopoulos, K. (2011) Biochem J 434, 365-81.
  2. Stehling, O. et al. (2012) Science 337, 195-9.
  3. Gari, K. et al. (2012) Science 337, 243-5.
  4. Vashisht, A.A. et al. (2015) J Biol Chem 290, 14218-25.
  5. Wu, X. et al. (2001) J Biol Chem 276, 23962-8.
  6. Ito, S. et al. (2010) Mol Cell 39, 632-40.
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Swiss-Prot Acc.
For Research Use Only. Not For Use In Diagnostic Procedures.

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