Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
MMS19 (D5J8J) Rabbit mAb recognizes endogenous levels of total MMS19 protein.
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu892 of human MMS19 protein.
Iron-sulfur (Fe-S) clusters (ISC) are cofactors for many proteins that display a wide range of biological functions, such as DNA maintenance, transcription, translation, cellular metabolism, electron transport, and oxidative phosphorylation (1). While structurally simple, the synthesis and insertion of ISC into Fe-S proteins are complex processes that involve many different proteins. MMS19 (methyl-methanesulfonate sensitivity 19) is a key component of the cytosolic Fe-S protein assembly complex, acting as an adaptor for a subset of Fe-S proteins including XPD and FANCJ, therefore playing an important role in DNA repair and transcription (2-4). MMS19 may also function as a coactivator for the estrogen receptor (5). In addition it has been reported that MMS19 is in a complex that is localized to the mitotic spindle and is required for proper chromosome segregation during mitosis (6).
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