Render Target: STATIC
Render Timestamp: 2024-12-06T11:14:24.472Z
Commit: 224419269841c11382c4555dbee545259bf6c379
XML generation date: 2024-08-01 15:28:49.546
Product last modified at: 2024-10-28T11:30:10.110Z
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PDP - Template Name: Polyclonal Antibody
PDP - Template ID: *******59c6464

MT-ATP8 Antibody #17412

Filter:
  • WB
  • IP

    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 9
    SOURCE Rabbit
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:50

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    MT-ATP8 Antibody recognizes endogenous levels of total MT-ATP8 protein.

    Species Reactivity:

    Human

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human MT-ATP8 protein. Antibodies are purified by peptide affinity chromatography.

    Background

    Mitochondrially-encoded ATP Synthase Membrane Subunit 8 (MT-ATP8) is a product of MT-ATP8, one of 13 protein-encoding genes in the human mitochondrial genome (1). MT-ATP8 comprises one subunit (ATP synthase FO subunit 8) of mitochondrial ATP synthase (Complex V), the inner mitochondrial enzyme that catalyzes the final step of oxidative phosphorylation in the electron transport chain (2). Numerous mutations in MT-ATP8 have been identified that have deleterious effects on ATP synthase function, some of which manifest as debilitating neuronal and/or neuromuscular diseases, including epilepsy, schizophrenia, autism, ataxia, and various cardiomyopathies (3), underscoring the importance of healthy mitochondrial function to organismal health.
    For Research Use Only. Not For Use In Diagnostic Procedures.
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