Render Target: STATIC
Render Timestamp: 2024-10-11T09:49:15.573Z
Commit: 56767fe525c928647c8401233a175d0d607d385d
XML generation date: 2024-09-20 06:22:28.931
Product last modified at: 2024-10-09T12:45:10.894Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

MUC4 β (D4W9X) XP® Rabbit mAb #81692

Filter:
  • WB
  • IHC

    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 100-170
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IHC-Immunohistochemistry 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunohistochemistry (Paraffin) 1:250 - 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    MUC4 β (D4W9X) XP® Rabbit mAb recognizes endogenous levels of total MUC4 protein (β subunit).

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the amino terminus of human MUC4 protein (β subunit).

    Background

    MUC4 is a membrane-bound mucin family member (1,2). It is a heterodimer of extracellular α subunits associated with a trans-membrane β subunit. There are 3 epidermal growth factor (EGF)-like domains in the extracellular region of the β subunit. These EGF-like domains can directly interact with ErbB2 to activate the downstream signaling pathways. MUC4 is expressed in the epithelial tissues of lung and gastrointestinal organs during development as well as in adult stage. It exerts a protective effect to these tissues against potential damage (3). Overexpression of MUC4 has been found in multiple types of cancers to promote cancer growth, survival, and metastasis (4-6). MUC4 has been proposed as a promising prognostic marker for cancer evaluation.
    For Research Use Only. Not For Use In Diagnostic Procedures.
    Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
    SignalStain is a registered trademark of Cell Signaling Technology, Inc.
    XP is a registered trademark of Cell Signaling Technology, Inc.
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