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Product Usage Information

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

Musashi-1 (D46A8) Rabbit mAb detects endogenous levels of total Musashi-1 protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Met190 of human Musashi-1 protein.

Musashi-1 and Musashi-2 are RNA-binding proteins which play a role in asymmetric cell division of ectodermal precursor cells by regulating the translation of target mRNA. Both family members augment Notch signaling and repress the translation of m-Numb, a protein that positively modulates differentiation of neural stem cells into neurons. Thus, Musashi contributes to the maintenance of neural stem cells (1). While Musashi-1 is frequently used as a marker for proliferating neural precursor cells, it is also expressed in epithelial stem cells including intestinal and mammary gland stem cells (2-4).

1.  Okano, H. et al. (2005) Exp. Cell Res. 306, 349-56.

2.  Sakakibara, S. et al. (1996) Dev. Biol. 176, 230-42.

3.  Potten, C.S. et al. (2003) Differentiation 71, 28-41.

4.  Clarke, R.B. et al. (2005) Dev. Biol. 277, 443-56.

Entrez-Gene Id 4440
Swiss-Prot Acc. O43347

For Research Use Only. Not For Use In Diagnostic Procedures.
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Musashi-1 (D46A8) Rabbit mAb