Render Target: STATIC
Render Timestamp: 2024-11-01T09:39:19.288Z
Commit: 23cb9f61fe67e1e9093fd644a533c4ff516a6463
XML generation date: 2024-09-30 01:57:30.242
Product last modified at: 2024-09-30T08:02:22.040Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

MX2 (E7Y8H) Rabbit mAb #43924

Filter:
  • WB

    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 80
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    MX2 (E7Y8H) Rabbit mAb recognizes endogenous levels of total MX2 protein.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asn175 of human MX2 protein.

    Background

    Mx2 (MxB) is a dynamin-like GTPase that is highly upregulated by IFN-α and IFN-β and upregulated to a lesser extent by IFN-γ (1). It was identified as a potent cell-autonomous HIV restriction factor (2). Mx2 functions as an HIV restriction factor by blocking infection at the late post-entry step through prevention of nuclear accumulation and chromosomal integration (2). HIV restriction by Mx2 is dictated through the capsid region of the viral Gag protein (2).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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