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MX2 (E7Y8H) Rabbit Monoclonal Antibody #43924

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  • WB

    Product Specifications

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 80
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    MX2 (E7Y8H) Rabbit Monoclonal Antibody recognizes endogenous levels of total MX2 protein.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asn175 of human MX2 protein.

    Background

    Mx2 (MxB) is a dynamin-like GTPase that is highly upregulated by IFN-α and IFN-β and upregulated to a lesser extent by IFN-γ (1). It was identified as a potent cell-autonomous HIV restriction factor (2). Mx2 functions as an HIV restriction factor by blocking infection at the late post-entry step through prevention of nuclear accumulation and chromosomal integration (2). HIV restriction by Mx2 is dictated through the capsid region of the viral Gag protein (2).

    Alternate Names

    Interferon-induced GTP-binding protein Mx2; Interferon-regulated resistance GTP-binding protein MxB; MX dynamin like GTPase 2; MX2; MXB; myxovirus (influenza virus) resistance 2; myxovirus (influenza virus) resistance 2 (mouse); Myxovirus resistance protein 2; p78-related protein; second interferon-induced protein p78

    For Research Use Only. Not for Use in Diagnostic Procedures.
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