NFKBID (F8U2O) Rabbit mAb #71044
- WB
Supporting Data
| REACTIVITY | H M Mk |
| SENSITIVITY | Endogenous |
| MW (kDa) | 35 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- Mk-Monkey
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
Like other IκBs, NFKBID and other atypical IκBs contain ankyrin repeats in their structure and act to modulate the NF-κB pathway. However, unlike typical IκB proteins, they do not actively repress nuclear localization of NF-κB proteins (1-5). NFKBID can change NF-κB-mediated transcription in a few ways: regulation of dimer formation, recruitment of histone-modifying enzymes, or stabilization of NF-κB proteins binding to DNA (5).
NFKBID is the smallest member of the Bcl-3 subfamily (6). NFKBID has been shown to interact with several different NF-κB dimers in the nucleus and plays a role in regulatory T cell (Treg) development in the thymus (7). NFKBID is important for IL-2-mediated stimulation of CD4 and CD8 cells (8). Mice deficient for NFKBID or c-REL show similar defects in adaptive and innate immune cell function (9,10).
- Hövelmeyer, N. et al. (2022) J Mol Med (Berl) 100, 985-995.
- Hayden, M.S. and Ghosh, S. (2012) Genes Dev 26, 203-34.
- Ghosh, S. and Hayden, M.S. (2008) Nat Rev Immunol 8, 837-48.
- Mankan, A.K. et al. (2009) J Cell Mol Med 13, 631-43.
- Schuster, M. et al. (2013) Cell Commun Signal 11, 23.
- Fiorini, E. et al. (2002) Mol Cell 9, 637-48.
- Schuster, M. et al. (2012) Immunity 37, 998-1008.
- Touma, M. et al. (2007) J Immunol 179, 1681-92.
- Schuster, M. et al. (2019) Front Immunol 10, 1583.
- Schuster, M. et al. (2017) J Immunol 199, 920-930.
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