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13407
OGDH Antibody

OGDH Antibody #13407

This product is discontinued

We recommend the following alternatives

  • WB
  • IP
H M R Mk
Storage:

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

OGDH Antibody recognizes endogenous levels of total OGDH protein.

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala110 of mouse OGDH protein. Antibodies are purified by protein A and peptide affinity chromatography.

2-oxoglutarate dehydrogenase (OGDH) is one of three enzymes in the α ketoglutarate dehydrogenase complex (OGDC) that is responsible for catalyzing a rate-regulating step of the tricarboxylic acid (Krebs) cycle. Together with dihydrolipoamide S-succinyltransferase (DLST) and dihydrolipoamide dehydrogenase (DLD), OGDH helps to convert 2-oxoglutarate to succinyl-CoA and CO2 within eukaryotic mitochondria (1). Regulation of this enzyme complex is important for mitochondrial energy metabolism within cells (2). Research studies indicate that OGDH activity within the mitochondrial matrix is regulated by multiple factors, including calcium, the adenine nucleotides ATP and ADP, and NADH (2).

  1. Sun, R.C. and Denko, N.C. (2014) Cell Metab 19, 285-92.
  2. Armstrong, C.T. et al. (2014) Biochem J 459, 369-81.
Entrez-Gene Id
4967
Swiss-Prot Acc.
Q02218
For Research Use Only. Not For Use In Diagnostic Procedures.

Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
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