P2X7 Receptor (E1E8T) Rabbit mAb #13809
- WB
- IP
Supporting Data
REACTIVITY | H |
SENSITIVITY | Endogenous |
MW (kDa) | 78 |
Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
Application | Dilution |
---|---|
Western Blotting | 1:1000 |
Immunoprecipitation | 1:50 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
Purinoceptor 7 (P2X7) is a homotrimer involved in diverse cellular responses, including inflammation mediated by phospholipase A2, phospholipase D, MAP kinase, and NF-κB activation (3,4). Research studies suggest that P2X7 receptors promote apoptosis by regulating release of IL-1β in neurodegenerative disorders associated with inflammation (5). Microglial P2X7 receptors may contribute to neuroinflammatory responses in the ATP-rich site of neuronal injury (6) and mediate inflammatory pain (7, 8). Association studies demonstrate a possible causal link between P2RX7 gene polymorphisms and susceptibility to bipolar affective disorder and major depressive disorder (9,10).
- North, R.A. (2002) Physiol Rev 82, 1013-67.
- Valera, S. et al. (1994) Nature 371, 516-9.
- North, R.A. and Surprenant, A. (2000) Annu Rev Pharmacol Toxicol 40, 563-80.
- Skaper, S.D. et al. (2010) FASEB J 24, 337-45.
- Bernardino, L. et al. (2008) J Neurochem 106, 271-80.
- Volonté, C. et al. (2003) Curr Drug Targets CNS Neurol Disord 2, 403-12.
- Chessell, I.P. et al. (2005) Pain 114, 386-96.
- Dell'Antonio, G. et al. (2002) Neurosci Lett 327, 87-90.
- Barden, N. et al. (2006) Am J Med Genet B Neuropsychiatr Genet 141B, 374-82.
- Lucae, S. et al. (2006) Hum Mol Genet 15, 2438-45.
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