Pan Na Channel alpha Subunit (D2I9C) Rabbit Monoclonal Antibody #14380
- WB
- IP
Product Specifications
| REACTIVITY | H M R |
| SENSITIVITY | Endogenous |
| MW (kDa) | 230-260 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:50 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
There are 9 mammalian alpha subunits, named Nav1.1-Nav1.9 (5). These alpha subunits differ in tissue specificity and biophysical functions (6,7). Seven of these subunits are essential for the initiation and propagation of action potentials in the central and peripheral nervous system while Nav1.4 and Nav1.5 are mainly expressed in skeletal muscle and cardiac muscle (8,9). Mutations in these alpha channel subunits have been identified in patients with epilepsy, seizure, ataxia, sensitivity to pain, and cardiomyopathy (reviewed in 10).
- Catterall, W.A. (2000) Neuron 26, 13-25.
- Yu, F.H. and Catterall, W.A. (2003) Genome Biol 4, 207.
- Isom, L.L. et al. (1994) Neuron 12, 1183-94.
- Yu, F.H. et al. (2003) J Neurosci 23, 7577-85.
- Goldin, A.L. et al. (2000) Neuron 28, 365-8.
- Plummer, N.W. and Meisler, M.H. (1999) Genomics 57, 323-31.
- Goldin, A.L. (2001) Annu Rev Physiol 63, 871-94.
- George, A.L. et al. (1992) Ann Neurol 31, 131-7.
- Ou, Y. et al. (2002) Neurogastroenterol Motil 14, 477-86.
- Meisler, M.H. and Kearney, J.A. (2005) J Clin Invest 115, 2010-7.
Alternate Names
BFIC3; BFIS3; BFIS5; BFNIS; cardiac sodium channel alpha subunit; cardiac tetrodotoxin-insensitive voltage-dependent sodium channel alpha subunit; CDCD2; CerIII; CIAT; CMD1E; CMPD2; CMS16; CTC-264K15.6; EA9; EIEE11; EIEE13; EIEE6; ETHA; FEB3; FEB3A; FEB3B; FEPS2; FEPS3; FHM3; GEFSP2; GEFSP7; HB1; HB2; HBA; HBBD; HBSC II; HBSCI; HBSCII; HH1; hNa6/Scn8a voltage-gated sodium channel; hNaN; hNE-Na; HOKPP2; hPN3; HSAN2D; HSAN7; HYKPP; HYPP; ICCD; IVF; LQT3; MED; motor endplate disease; MYOCL2; Na(v)1.2; Na(V)1.4; NAC1; NAC1A; NAC2; NaCh6; NaG; NaN; Nav1.1; Nav1.2; Nav1.4; Nav1.5; Nav1.6; Nav1.7; Nav1.8; NAV1.9; Nav2.1; Nav2.2; NE-NA; NENA; Neuroendocrine sodium channel; Peripheral nerve sodium channel 3; Peripheral nerve sodium channel 5; Peripheral sodium channel 1; PFHB1; PN1; PN3; PN4; PN5; Putative voltage-gated sodium channel subunit alpha Nax; SCN1; SCN10A; SCN11A; SCN12A; SCN1A; SCN2A; SCN2A1; SCN2A2; SCN4A; SCN5A; SCN6A; SCN7A; SCN8A; SCN9A; SCNAA; SCNBA; Sensory neuron sodium channel 2; SFNP; skeletal muscle sodium channel alpha subunit; skeletal muscle voltage-dependent sodium channel type IV alpha subunit; SkM1; SMEI; SNS; SNS-2; SNS2; Sodium channel protein brain I subunit alpha; Sodium channel protein brain II subunit alpha; Sodium channel protein cardiac and skeletal muscle subunit alpha; Sodium channel protein cardiac muscle subunit alpha; Sodium channel protein skeletal muscle subunit alpha; Sodium channel protein type 1 subunit alpha; Sodium channel protein type 10 subunit alpha; Sodium channel protein type 11 subunit alpha; Sodium channel protein type 2 subunit alpha; Sodium channel protein type 4 subunit alpha; Sodium channel protein type 5 subunit alpha; Sodium channel protein type 7 subunit alpha; Sodium channel protein type 8 subunit alpha; Sodium channel protein type 9 subunit alpha; Sodium channel protein type I subunit alpha; Sodium channel protein type II subunit alpha; Sodium channel protein type IV subunit alpha; Sodium channel protein type IX subunit alpha; sodium channel protein type V alpha subunit; Sodium channel protein type V subunit alpha; Sodium channel protein type VII subunit alpha; Sodium channel protein type VIII subunit alpha; Sodium channel protein type X subunit alpha; Sodium channel protein type XI subunit alpha; sodium channel protein, brain I alpha subunit; sodium channel protein, brain type 2 alpha subunit; sodium channel voltage gated type 1 alpha subunit; sodium channel, voltage gated, type VIII, alpha subunit; sodium channel, voltage-gated, type I, alpha polypeptide; sodium channel, voltage-gated, type I, alpha subunit; sodium channel, voltage-gated, type II, alpha 1 polypeptide; sodium channel, voltage-gated, type II, alpha 2 polypeptide; sodium channel, voltage-gated, type II, alpha subunit; sodium channel, voltage-gated, type IV, alpha subunit; sodium channel, voltage-gated, type IX, alpha polypeptide; sodium channel, voltage-gated, type IX, alpha subunit; sodium channel, voltage-gated, type V, alpha subunit; sodium channel, voltage-gated, type VI, alpha polypeptide; sodium channel, voltage-gated, type VII, alpha; sodium channel, voltage-gated, type VII, alpha polypeptide; sodium channel, voltage-gated, type VII, alpha subunit; sodium channel, voltage-gated, type X, alpha polypeptide; sodium channel, voltage-gated, type X, alpha subunit; sodium channel, voltage-gated, type XI, alpha polypeptide; sodium channel, voltage-gated, type XI, alpha subunit; sodium channel, voltage-gated, type XII, alpha polypeptide; sodium voltage-gated channel alpha subunit 1; sodium voltage-gated channel alpha subunit 10; sodium voltage-gated channel alpha subunit 11; sodium voltage-gated channel alpha subunit 2; sodium voltage-gated channel alpha subunit 4; sodium voltage-gated channel alpha subunit 5; sodium voltage-gated channel alpha subunit 7; sodium voltage-gated channel alpha subunit 8; sodium voltage-gated channel alpha subunit 9; SSS1; VF1; voltage-dependent sodium channel alpha subunit; voltage-gated sodium channel alpha subunit Nav1.7; voltage-gated sodium channel Nav1.9; voltage-gated sodium channel subtype II; Voltage-gated sodium channel subunit alpha Nav1.1; Voltage-gated sodium channel subunit alpha Nav1.2; Voltage-gated sodium channel subunit alpha Nav1.4; Voltage-gated sodium channel subunit alpha Nav1.5; Voltage-gated sodium channel subunit alpha Nav1.6; Voltage-gated sodium channel subunit alpha Nav1.7; Voltage-gated sodium channel subunit alpha Nav1.8; Voltage-gated sodium channel subunit alpha Nav1.9; voltage-gated sodium channel type II alpha subunit; voltage-gated sodium channel type VIII alpha protein
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