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R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

PANK2 (D11E2) Rabbit mAb #12479

Filter:
  • WB
  • IP

    Supporting Data

    REACTIVITY M
    SENSITIVITY Endogenous
    MW (kDa) 49
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • M-Mouse 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:50

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    PANK2 (D11E2) Rabbit mAb recognizes endogenous levels of total PANK2 protein.

    Species Reactivity:

    Mouse

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu76 of mouse PANK2 protein.

    Background

    Pantothenate kinase 2 (PANK2) catalyzes the first step in coenzyme A (CoA) biosynthesis (1,2). Human PANK2 protein is located in the mitochondria, and research studies have shown some mutations in human PANK2 are linked to neurodegeneration (2). Alternatively, mouse PANK2 protein localizes in the cytosol, and defective PANK2 protein in mice leads to retinal degeneration (1,3).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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