Render Target: STATIC
Render Timestamp: 2024-10-14T09:38:35.131Z
Commit: 56767fe525c928647c8401233a175d0d607d385d
XML generation date: 2024-04-24 20:37:09.993
Product last modified at: 2024-06-07T08:00:11.991Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

PD-L1 (Atezolizumab Biosimilar) Human mAb #33052

    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa)
    Source/Isotype Human IgG1 kappa
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Description

    PD-L1 (Atezolizumab Biosimilar) Human mAb is a biosimlar antibody for Atezolizumab. Atezolizumab is a human monoclonal antibody directed against PD-L1 that is designed to function as an immune checkpoint inhibitor by disrupting the interaction between PD-L1 and PD-1.
    Endotoxin <0.1 EU/μg of antibody

    Product Usage Information

    This product is intended for research use only (RUO). Optimal dilutions/concentrations should be determined by the end user.

    Formulation

    Supplied in 1X PBS, BSA and Azide Free.

    Storage

    Store at -20°C. This product will freeze at -20°C so it is recommended to aliquot into single-use vials to avoid multiple freeze/thaw cycles. A slight precipitate may be present and can be dissolved by gently vortexing. This will not interfere with antibody performance.

    Specificity / Sensitivity

    PD-L1 (Atezolizumab Biosimilar) Human mAb was confirmed to bind to its intended target protein PD-L1 using flow cytometry and bio-layer interferometry.

    Species Reactivity:

    Human

    Source / Purification

    PD-L1 (Atezolizumab Biosimilar) Human mAb is produced at Cell Signaling Technology. Atezolizumab is an antibody that is directed against the extracellular region of human PD-L1.

    Background

    Programmed cell death 1 ligand 1 (PD-L1, B7-H1, CD274) is a member of the B7 family of cell surface ligands that regulate T cell activation and immune responses. The PD-L1 ligand binds the PD-1 transmembrane receptor and inhibits T cell activation. PD-L1 was discovered following a search for novel B7 protein homologs and was later shown to be expressed by antigen presenting cells, activated T cells, and tissues including placenta, heart, and lung (1-3). Similar in structure to related B7 family members, PD-L1 protein contains extracellular IgV and IgC domains and a short, cytoplasmic region. Research studies demonstrate that PD-L1 is expressed in several tumor types, including melanoma, ovary, colon, lung, breast, and renal cell carcinomas (4-6). Expression of PD-L1 in cancer is associated with tumor-infiltrating lymphocytes, which mediate PD-L1 expression through the release of interferon gamma (7). Additional research links PD-L1 expression to cancers associated with viral infections (8,9).
    For Research Use Only. Not For Use In Diagnostic Procedures.
    Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
    All other trademarks are the property of their respective owners. Visit our Trademark Information page.