|PFKFB2 (D5I5F) Rabbit mAb 13029||100 µl||H Mk||55||Rabbit IgG|
|Phospho-PFKFB2 (Ser483) (D4R1W) Rabbit mAb 13064||100 µl||H||55||Rabbit IgG|
The bifunctional 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK/FBPase or PFKFB) catalyzes the synthesis and degradation of fructose 2,6-bisphosphate and regulates its steady-state level (1,2). Fructose 2,6-bisphosphate activates phosphofructokinase, a rate-limiting enzyme in glycolysis, by allosteric regulation (1,2). Four different PFKFB isoforms (PFKFB1, PFKFB2, PFKFB3, and PFKFB4) have been identified (1,2). Research studies indicate that amino acids activate PFKFB2 through Akt-dependent phosphorylation at Ser483 on PFKFB2 (3). In addition, androgen increases the expression of PFKFB2 in prostate cancer cells (4).
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UniProt ID: O60825
Entrez-Gene Id: 5208
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