Render Target: STATIC
Render Timestamp: 2025-03-19T11:06:28.975Z
Commit: 779953b12a5930618aae6aca7c87fb286faeb1d7
XML generation date: 2025-03-07 13:17:37.578
Product last modified at: 2025-01-01T09:03:35.937Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

PGLYRP-1/PGRP-S (E3V2X) Rabbit mAb #71789

Filter:
  • WB

    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 20-30
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    PGLYRP-1/PGRP-S (E3V2X) Rabbit mAb recognizes endogenous levels of total PGLYRP-1/PGRP-S protein.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the amino terminus of human PGLYRP-1/PGRP-S protein.

    Background

    The human peptidoglycan recognition protein (PGRP) family is composed of four independent genes named for the relative length of their translated product. Human PGRP family proteins are soluble pattern-recognition receptors of the innate immune response that bind peptidoglycan and Gram-positive bacteria, and have direct bactericidal activity (1,2). PGRP-short (PGRP-S), also known as PGLYRP-1 and Tag7, is 196 amino acids (aa) in length (3). PGLYRP-1/PGRP-S is a secreted glycoprotein expressed by neutrophils that participates in killing phagocytized bacteria (4,5). PGLYRP-1/PGRP-S also has been shown to form a stable cytotoxic complex with the heat shock protein Hsp70 to induce tumor cell death (6,7). PGRP-long (PGRP-L), also known as PGLYRP-2, is 576 aa long. PGLYRP-2/PGRP-L is an N-acetylmuramoyl-L-alanine amidase that hydrolyzes bacterial peptidoglycan (8,9). PGRP-intermediate alpha, also known as PGLYRP-3, and PGRP-intermediate beta, also known as PGLYRP-4, are 341 aa and 373 aa long, respectively. PGLYRP-3 and PGLYRP-4 are co-expressed in the same cells and are exclusively secreted as homo- or heterodimers with antibacterial function (10).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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    KARPAS cell line source: Dr. Abraham Karpas at the University of Cambridge.
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