Phospho-PANK2 (Ser169) (F7O5Q) Rabbit mAb #88224
- WB
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 50 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
Studies show that PI3K/Akt signaling induces de novo CoA biosynthesis. CoA is a key metabolic cofactor in many metabolic processes, including the tricarboxylic acid (TCA) cycle and fatty acid metabolism, and is synthesized from pantothenate, cysteine, and ATP. Purified Akt kinase phosphorylates PANK2 in vitro. This phosphorylation is abolished when Ser169 and Ser189 residues on PANK2 are replaced by amino acid alanine (4).
Limited Uses
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