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Phospho-RIP2 (Ser176) (E1I9J) Rabbit mAb
Primary Antibodies

Phospho-RIP2 (Ser176) (E1I9J) Rabbit mAb #14397

This product is discontinued


Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

Phospho-RIP2 (Ser176) (E1I9J) Rabbit mAb recognizes endogenous levels of RIP2 protein only when phosphorylated at Ser176. This antibody also cross-reacts with unidentified proteins of approximately 25 kDa and 38 kDa in some cell lines.

Monoclonal antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Ser176 of human RIP2 protein.

Receptor Interacting Protein 2 (RIP2) is a serine/threonine kinase with a carboxy-terminal caspase activation and recruitment domain (CARD). Association of RIP2 with the tumor necrosis factor receptor (TNFR) causes activation of NF-κB and induction of apoptosis (1-3). Expression of RIP2 is induced in macrophages upon exposure to bacterial cell wall components, such as LPS. RIP2-deficient mouse models demonstrate that this kinase integrates and transduces signals for both the innate and adaptive immune system (4,5).

The RIP2 Ser176 residue serves as a regulatory autophosphorylation site and can be used to monitor the activation state of RIP2 (6).

  1. Inohara, N. et al. (1998) J Biol Chem 273, 12296-300.
  2. McCarthy, J.V. et al. (1998) J Biol Chem 273, 16968-75.
  3. Thome, M. et al. (1998) Curr Biol 8, 885-8.
  4. Chin, A.I. et al. (2002) Nature 416, 190-4.
  5. Kobayashi, K. et al. (2002) Nature 416, 194-9.
  6. Dorsch, M. et al. (2006) Cell Signal 18, 2223-9.
Entrez-Gene Id
Swiss-Prot Acc.
For Research Use Only. Not For Use In Diagnostic Procedures.

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