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Primary Antibodies /
Phospho-RSK3 (Thr353/356) Antibody

Phospho-RSK3 (Thr353/356) Antibody #9345

Inquiry Info. # 9345

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Product Specifications

REACTIVITY
SENSITIVITY
MW (kDa)	90
SOURCE	Rabbit

Product Information

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

Phospho-RSK3 (Thr353/356) Antibody detects endogenous levels of RSK3 only when phosphorylated at Thr353/356. This antibody does not recognize RSK3 phosphorylated at other sites, nor does it cross-react with phospho- RSK1, -RSK2 or -MSK1.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Thr353/356 of human RSK3. Antibodies are purified by protein A and peptide affinity chromatography.

Background

The 90 kDa ribosomal S6 kinases (RSK1-4) are a family of widely expressed Ser/Thr kinases characterized by two nonidentical, functional kinase domains (1) and a carboxy-terminal docking site for extracellular signal-regulated kinases (ERKs) (2). Several sites both within and outside of the RSK kinase domain, including Ser380, Thr359, Ser363, and Thr573, are important for kinase activation (3). RSK1-3 are activated via coordinated phosphorylation by MAPKs, autophosphorylation, and phosphoinositide-3-OH kinase (PI3K) in response to many growth factors, polypeptide hormones, and neurotransmitters (3).

Alternate Names

90 kDa ribosomal protein S6 kinase 2; HU-2; KS6A2; MAP kinase-activated protein kinase 1c; MAPK-activated protein kinase 1c; MAPKAP kinase 1c; MAPKAPK-1c; MAPKAPK1C; mitogen-activated protein kinase-activated protein kinase 1C; p90-RSK 2; p90-RSK3; p90RSK2; pp90RSK3; ribosomal protein S6 kinase A2; ribosomal protein S6 kinase alpha 2; Ribosomal protein S6 kinase alpha-2; ribosomal protein S6 kinase, 90kDa, polypeptide 2; Ribosomal S6 kinase 3; RPS6KA2; RSK; RSK-3; RSK3; S6K-alpha; S6K-alpha-2; S6K-alpha2

Database Links

UniProt ID: Q15349

Entrez-Gene Id: 6196

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For Research Use Only. Not for Use in Diagnostic Procedures.

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