Phospho-SGTA (Ser305) (D23E10) Rabbit mAb #8664
- WB
- IP
Supporting Data
| REACTIVITY | H Mk |
| SENSITIVITY | Endogenous |
| MW (kDa) | 34 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
- Mk-Monkey
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:100 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
Phosphorylation of SGTA at Ser305 was identified at Cell Signaling Technology (CST) using PhosphoScan®, a CST™ LC-MS/MS platform for phosphorylation site discovery (7). Site-specific mutation analysis indicated that phosphorylation at Ser305 is essential for PDGFR α stabilization and PDGFR α-dependent cancer cell survival (7).
- Liu, F.H. et al. (1999) J Biol Chem 274, 34425-32.
- Tobaben, S. et al. (2003) J Biol Chem 278, 38376-83.
- Cziepluch, C. et al. (1998) J Virol 72, 4149-56.
- Scheufler, C. et al. (2000) Cell 101, 199-210.
- Liou, S.T. and Wang, C. (2005) Arch Biochem Biophys 435, 253-63.
- Yin, H. et al. (2006) Biochem Biophys Res Commun 343, 1153-8.
- Moritz, A. et al. (2010) Sci Signal 3, ra64.
Limited Uses
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