Phospho-Smad3 (Ser423/425)/Smad1 (Ser463/465) Antibody #9514
Inquiry Info. # 9514
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Product Specifications
| REACTIVITY | |
| SENSITIVITY | Endogenous |
| MW (kDa) | 60 |
| SOURCE | Rabbit |
Product Information
Storage
Specificity / Sensitivity
Source / Purification
Background
Following stimulation by TGF-β, Smad2 and Smad3 become phosphorylated at their carboxyl termini (Ser465 and 467 on Smad2; Ser423 and 425 on Smad3) by TGF-β Receptor I. Phosphorylated Smad 2/3 can complex with Smad4, translocate to the nucleus and regulate gene expression (9-11).
- Heldin, C.H. et al. (1997) Nature 390, 465-71.
- Attisano, L. and Wrana, J.L. (1998) Curr Opin Cell Biol 10, 188-94.
- Derynck, R. et al. (1998) Cell 95, 737-40.
- Massagué, J. (1998) Annu Rev Biochem 67, 753-91.
- Whitman, M. (1998) Genes Dev 12, 2445-62.
- Wrana, J.L. (2000) Sci STKE 2000, re1.
- Attisano, L. and Wrana, J.L. (2002) Science 296, 1646-7.
- Moustakas, A. et al. (2001) J Cell Sci 114, 4359-69.
- Abdollah, S. et al. (1997) J. Biol. Chem. 272, 27678-27685.
- Souchelnytskyi, S. et al. (1997) J. Biol. Chem. 272, 28107-28115.
- Liu, X. et al. (1997) Proc. Natl. Acad. Sci. USA 94, 10669-10674.
Alternate Names
BSP-1; BSP1; DKFZp586N0721; DKFZp686J10186; hMAD-3; hSMAD1; hSMAD3; HSPC193; HsT17436; JV15-2; JV4-1; JV41; LDS1C; LDS3; MAD homolog 1; MAD homolog 3; mad homolog JV15-2; mad protein homolog; Mad-related protein 1; MAD, mothers against decapentaplegic homolog 1; MAD, mothers against decapentaplegic homolog 3; Mad3; MADH1; MADH3; MADR1; MGC60396; Mothers against decapentaplegic homolog 1; Mothers against decapentaplegic homolog 3; Mothers against DPP homolog 1; Mothers against DPP homolog 3; SMA- and MAD-related protein 3; SMAD 1; SMAD 3; SMAD family member 1; SMAD family member 3; SMAD, mothers against DPP homolog 1; SMAD, mothers against DPP homolog 3; SMAD1; SMAD3; TGF-beta signaling protein 1; transforming growth factor-beta signaling protein 1; Transforming growth factor-beta-signaling protein 1
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