Phospho-TFE3 (Ser321) Matched Antibody Pair #70104
- ELISA
Product Specifications
| REACTIVITY | H M R Mk |
Application Key:
- ELISA-ELISA
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
- Mk-Monkey
Product Information
Product Usage Information
Formulation
Storage
Product Description
The Phospho-TFE3 (Ser321) Matched Antibody Pair is ideal for use with immunoassay technologies and high-throughput ELISA platforms requiring antibody pairs with specialized or custom antibody labeling. Labels include fluorophores, lanthanides, biotin, and beads. Platforms requiring conjugated Matched Antibody Pairs include MSD, Quanterix Simoa, Alpha Technology (AlphaScreen, AlphaLISA, LANCE, HTRF), and Luminex.
Learn how Matched Antibody Pairs move your projects forward, faster at cst-science.com/matched-antibody-pairs.
Background
Phosphorylation of TFE3 at Ser321 by mTOR leads to cytoplasmic retention analogous to Ser211 on TFEB (6). Dephosphorylation of TFEB and TFE3 by protein phosphatase 2A in response to oxidative stress leads to their nuclear translocation and activation (7).
- Miller, A.J. et al. (2005) J Biol Chem 280, 146-55.
- Martina, J.A. et al. (2014) Cell Mol Life Sci 71, 2483-97.
- Martina, J.A. et al. (2014) Sci Signal 7, ra9.
- Betschinger, J. et al. (2013) Cell 153, 335-47.
- Kauffman, E.C. et al. (2014) Nat Rev Urol 11, 465-75.
- Wada, S. et al. (2016) Genes Dev 30, 2551-2564.
- Martina, J.A. and Puertollano, R. (2018) J Biol Chem 293, 12525-12534.
Alternate Names
BHLHE33; class E basic helix-loop-helix protein 33; DKFZp761J1810; Putative uncharacterized protein DKFZp761J1810; RCCP2; RCCX1; TFE3; TFEA; transcription factor binding to IGHM enhancer 3; transcription factor E family, member A; Transcription factor E3; Transcription factor for IgH enhancer; transcription factor for immunoglobulin heavy-chain enhancer 3
Limited Uses
Except as otherwise expressly agreed in a writing signed by a legally authorized representative of CST, the following terms apply to Products provided by CST, its affiliates or its distributors. Any Customer's terms and conditions that are in addition to, or different from, those contained herein, unless separately accepted in writing by a legally authorized representative of CST, are rejected and are of no force or effect.
Products are labeled with For Research Use Only or a similar labeling statement and have not been approved, cleared, or licensed by the FDA or other regulatory foreign or domestic entity, for any purpose. Customer shall not use any Product for any diagnostic or therapeutic purpose, or otherwise in any manner that conflicts with its labeling statement. Products sold or licensed by CST are provided for Customer as the end-user and solely for research and development uses. Any use of Product for diagnostic, prophylactic or therapeutic purposes, or any purchase of Product for resale (alone or as a component) or other commercial purpose, requires a separate license from CST. Customer shall (a) not sell, license, loan, donate or otherwise transfer or make available any Product to any third party, whether alone or in combination with other materials, or use the Products to manufacture any commercial products, (b) not copy, modify, reverse engineer, decompile, disassemble or otherwise attempt to discover the underlying structure or technology of the Products, or use the Products for the purpose of developing any products or services that would compete with CST products or services, (c) not alter or remove from the Products any trademarks, trade names, logos, patent or copyright notices or markings, (d) use the Products solely in accordance with CST Product Terms of Sale and any applicable documentation, and (e) comply with any license, terms of service or similar agreement with respect to any third party products or services used by Customer in connection with the Products.