Phospho-VCP (Ser13) Antibody #87525
- WB
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Transfected Only |
| MW (kDa) | 89 |
| SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
The antigen sequence used to produce this antibody shares 100% sequence homology with the species listed here, but reactivity has not been tested or confirmed to work by CST. Use of this product with these species is not covered under our Product Performance Guarantee.
Species predicted to react based on 100% sequence homology:
Source / Purification
Background
Phosphorylation of VCP at Ser13, Ser282, and Thr761 by the autophagy kinase ULK1 can promote its ATPase activity and ability to disassemble stress granules (7).
- DeLaBarre, B. and Brunger, A.T. (2003) Nat. Struct. Biol. 10, 856-863.
- Huyton, T. et al. (2003) J. Struct. Biol. 144, 337-348.
- Dreveny, I. et al. (2004) EMBO J. 23, 1030-1039.
- Wang, Q. et al. (2004) J. Struct. Biol. 146, 44-57.
- Madeo, F. et al. (1998) Mol. Biol. Cell 9, 131-141.
- Livingstone, M. et al. (2005) Cancer Res. 65, 7533-7540.
- Wang, B. et al. (2019) Mol Cell 74, 742-757.e8.
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