Render Target: STATIC
Render Timestamp: 2024-12-03T10:49:46.348Z
Commit: cd2fae6ca3f811b1ddb1df24ac291ed56d5d501b
XML generation date: 2024-11-18 16:03:18.892
Product last modified at: 2024-11-19T09:00:13.946Z
1% for the planet logo
PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

PKN3 (F6S5C) Rabbit mAb #75243

Filter:
  • WB

    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 100
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    PKN3 (F6S5C) Rabbit mAb recognizes endogenous levels of total PKN3 protein.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val882 of human PKN3 protein.

    Background

    Protein Kinase N3 (PKN3) is a PKC-related protein kinase that acts downstream of Rho GTPases and PI3K, supporting tumor invasion, metastasis, and angiogenesis (1-3). PKN3 is highly expressed in cancer cells, and silencing PKN3 expression is under investigation as a means of treating human cancers (4). Atu027, a therapeutic siRNA that silences PKN3 expression in the vascular endothelium, has been shown to prevent or delay metastasis in human pancreatic cancer (5).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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