Cell Signaling Technology Logo - Extra Large
Trial Size Available Flag
Recombinant Flag
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

PPM1G (E7J2F) Rabbit Monoclonal Antibody #25249

Filter:
  • WB

    Product Specifications

    REACTIVITY H M R
    SENSITIVITY Endogenous
    MW (kDa) 72
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    PPM1G (E7J2F) Rabbit Monoclonal Antibody recognizes endogenous levels of total PPM1G protein.

    Species Reactivity:

    Human, Mouse, Rat

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Arg463 of human PPM1G protein.

    Background

    Protein phosphatase magnesium/manganese-dependent 1 gamma (PPM1G) is a metal-dependent protein phosphatase belonging to the PP2C/PPM family of Ser/Thr phosphatases. PPM1G is a ubiquitously expressed enzyme that binds magnesium/manganese cations in its active center (1). Research studies have demonstrated that PPM1G acts on numerous substrates to participate in a diverse array of biological processes, such as cell cycle control, protein translation, and antiviral innate immune signaling (2-4). In the context of human disease, PPM1G is highly expressed in hepatocellular carcinoma and may contribute to disease by enhancing cell proliferation and migration (5,6).

    Alternate Names

    MGC1675; MGC2870; PP2C-gamma; PP2C, gamma; PP2CG; PP2CGAMMA; PPM1C; PPM1G; PPP2CG; Protein phosphatase 1C; Protein phosphatase 1G; protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform; protein phosphatase 2, catalytic subunit, gamma isoform; protein phosphatase 2C gamma isoform; Protein phosphatase 2C isoform gamma; Protein phosphatase magnesium-dependent 1 gamma; protein phosphatase, Mg2+/Mn2+ dependent 1G; protein phosphatase, Mg2+/Mn2+ dependent, 1G

    For Research Use Only. Not for Use in Diagnostic Procedures.
    Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
    All other trademarks are the property of their respective owners. Visit our Trademark Information page.