PRSS8 (F2Z4K) Rabbit mAb #15986

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Supporting Data

REACTIVITY	H M R
SENSITIVITY	Endogenous
MW (kDa)	36
Source/Isotype	Rabbit IgG

Application Key:

WB-Western Blotting

Species Cross-Reactivity Key:

H-Human
M-Mouse
R-Rat

Product Information

Product Usage Information

Application	Dilution
Western Blotting	1:1000

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

PRSS8 (F2Z4K) Rabbit mAb recognizes endogenous levels of total PRSS8 protein.

Species Reactivity:

Human, Mouse, Rat

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val98 of human PRSS8 protein.

Background

Prostasin (PRSS8), also known as channel activating protease 1 (CAP1), is a glycosylphosphatidylinositol (GPI)-anchored serine protease that is ubiquitously expressed in many tissues, including the small intestine, colon, esophagus, stomach, lung, skin, liver, prostate, kidney, and gallbladder (1). It acts as a proteolytic activator of the epithelial sodium channel in vitro and plays a major role in regulating sodium balance and glucose homeostasis (1,2). Aberrant PRSS8 expression has been associated with multiple cancers, including ovarian, prostate, breast, bladder, and gastric cancers (1). PRSS8 has been identified as a potential biomarker for early detection of ovarian cancer and, more recently, for Alzheimer’s disease (2,3).

Database Links

UniProt ID: Q16651

Entrez-Gene Id: 5652

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For Research Use Only. Not For Use In Diagnostic Procedures.

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