Render Target: STATIC
Render Timestamp: 2024-11-01T09:39:13.324Z
Commit: 23cb9f61fe67e1e9093fd644a533c4ff516a6463
XML generation date: 2024-09-30 02:00:04.749
Product last modified at: 2024-10-24T22:00:09.281Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

PTN (F7T3F) Rabbit mAb #54934

Filter:
  • WB
  • IF

    Supporting Data

    REACTIVITY H M R
    SENSITIVITY Endogenous
    MW (kDa) 18
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IF-Immunofluorescence 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunofluorescence (Immunocytochemistry) 1:1600 - 1:6400

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    PTN (F7T3F) Rabbit mAb recognizes endogenous levels of total PTN protein.

    Species Reactivity:

    Human, Mouse, Rat

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human PTN protein.

    Background

    Pleiotrophin (PTN) is a heparin-binding, developmentally regulated cytokine that is independently identified by several groups; it is also known as heparin-binding brain mitogen (HBBM), heparin-binding growth factor-8 (HBGF-8), heparin-binding neurotrophic factor (HBNF), heparin-affinity regulatory peptide (HARP), heparin-binding growth-associated molecule (HB-GAM), and osteoblast-specific factor 1 (OSF-1) (1-6). PTN is highly upregulated during embryonic development and early cell differentiation. In adulthood, PTN expression decreases in most tissues except for the bone and the nervous system. It interacts with numerous cell surface proteoglycan and non-proteoglycan receptors, including protein tyrosine phosphatase receptor type Z (PTPRZ), syndecans, nucleolin, neuropilin-1, ALK, and integrin αVβ3 and αMβ2 (reviewed in 7-9). PTN has been associated with biological events that involve cellular proliferation, differentiation, and inflammation, including tissue regeneration, bone repair, hypoxia, tumor growth, and angiogenesis.
    For Research Use Only. Not For Use In Diagnostic Procedures.
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