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  2. Primary Antibodies /
  3. QSER1 (F6Z3K) Rabbit mAb
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

QSER1 (F6Z3K) Rabbit mAb #25444

Filter:
  • WB
  • IP
  • ChIP

    Supporting Data

    REACTIVITY H R Mk
    SENSITIVITY Endogenous
    MW (kDa) 250
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    • ChIP-Chromatin Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 
    • R-Rat 
    • Mk-Monkey 

    Product Information

    Product Usage Information

    For optimal ChIP results, use 10 μL of antibody and 10 μg of chromatin (approximately 4 × 106 cells) per IP. This antibody has been validated using SimpleChIP® Enzymatic Chromatin IP Kits.
    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:100
    Chromatin IP 1:50

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    QSER1 (F6Z3K) Rabbit mAb recognizes endogenous levels of total QSER1 protein. This antibody detects isoform 1 and isoform 2 of QSER1.

    Species Reactivity:

    Human, Rat, Monkey

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ser136 of human QSER1 protein.

    Background

    The glutamine and serine-rich protein 1 (QSER1) gene is located on human chromosome 11. A single nucleotide polymorphism (SNP) near the QSER1 locus has been associated with older age onset Parkinson’s disease through genome-wide association studies (1), and exome sequencing has suggested QSER1 could potentially serve as a marker of type 2 diabetes (2). More recently, it was shown that QSER1 cooperates with TET1 to protect DNA methylation valleys from de novo methylation mediated by DNMT3 (3). Recent reports have also found that QSER1 tends to be upregulated in multiple cancers, and this upregulation is associated with poor clinic outcomes (4,5).

    Database Links

    UniProt ID: Q2KHR3


    Entrez-Gene Id: 79832


    Limited Uses

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    For Research Use Only. Not For Use In Diagnostic Procedures.
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