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Rab38 Antibody #9688

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  • IP

Inquiry Info. # 9688

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    Product Specifications

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 23
    SOURCE Rabbit
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:50

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    Rab38 Antibody detects endogeneous levels of total Rab38 protein.

    Species Reactivity:

    Human

    The antigen sequence used to produce this antibody shares 100% sequence homology with the species listed here, but reactivity has not been tested or confirmed to work by CST. Use of this product with these species is not covered under our Product Performance Guarantee.

    Species predicted to react based on 100% sequence homology:

    Monkey

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val192 of human Rab38 protein. Antibodies are purified by protein A and peptide affinity chromatography.

    Background

    Rab38 is a member of the Rab small G protein family and is mainly expressed in lung alveolar type II cells and melanocytes (1,2). In mice, the G146T Rab38 gene mutation results in loss of Rab38 function and causes abnormal pigmentation due to the loss of melanosomes (3). The Rab38 gene locus has been mapped to oculocutaneous albinism in Ruby rats, a model of human Hermansky-Pudlak Syndrome (4). Analysis of lung structure in the G146T mutation in mice and the Rab38 null mutation in rats also revealed an altered lung surfactant system with enlarged lamellar bodies in type II cells, indicating a role for Rab38 in lung function and development (5,6). Dysfunction mutation studies implicate Rab38 in the post-Golgi trafficking of enzymes (e.g. TYRP1) related to melanogenesis and stability (7,8).

    Alternate Names

    Melanoma antigen NY-MEL-1; NY-MEL-1; Rab-related GTP-binding protein; RAB38; RAB38, member RAS oncogene family; Ras-related protein Rab-38; rrGTPbp

    For Research Use Only. Not for Use in Diagnostic Procedures.
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