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  3. Rag Protein Antibody Sampler Kit

Rag Protein Antibody Sampler Kit #9778

Inquiry Info. # 9778

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    Product Information

    Kit Usage Information

    Protocols

    Product Description

    The Rag Protein Antibody Sampler Kit provides an economical means to evaluate the regulation of mTORC1 signaling by such proteins as Raptor, RagA, RagB, RagC, and RagD. The kit contains enough primary and secondary antibodies to perform four Western blot experiments per primary antibody.

    Background

    The mTORC1 kinase complex is a critical regulator of cell growth (1,2). Its activity is modulated by energy levels, growth factors, and amino acids via signaling through Akt, MAPK, and AMPK pathways (3,4). Recent studies found that the four related GTPases, RagA, RagB, RagC, and RagD, interact with raptor within the mTORC1 complex (1,2). These interactions are both necessary and sufficient for mTORC1 activation in response to amino acid signals (1,2).

    Alternate Names

    FIP; FIP-1; FIP1; mTOR; mTORC; Rag; Rag A; Rag B; Rag C; Rag D; RagA; ragab; RagB; RagC; ragcd; RagD; Raptor; Ras-related GTP-binding protein; rasraf; RRAG; TOR

    Database Links

    UniProt ID: P42345 , Q8N122 , Q9HB90 , Q7L523 , Q9NQL2 , Q5VZM2


    Entrez-Gene Id: 2475 , 57521 , 64121 , 10670 , 58528 , 10325


    Limited Uses

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    For Research Use Only. Not for Use in Diagnostic Procedures.
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